Which of the following is an example of non-SCC oral cancer according to the material?

• A. Basal cell carcinoma of the lip
• B. Squamous cell carcinoma of the lip
• C. Ameloblastoma
• D. Osteosarcoma of the mandible

Answer: (A)

Oral cancers are most often squamous cell carcinomas that arise from the mucosal lining, but non-SCC oral cancers come from tissues other than the mucosa. Basal cell carcinoma of the lip originates in the epidermal basal cells of the lip skin rather than from the mucosal squamous epithelium, so it is a non-SCC cancer in this context. In contrast, squamous cell carcinoma of the lip is by definition SCC, so it isn’t the non-SCC example. Ameloblastoma is an odontogenic tumor, typically benign, and not classified as a malignant oral cancer. Osteosarcoma of the mandible is a bone sarcoma affecting the jaw, not a squamous carcinoma of mucosa. Therefore, basal cell carcinoma of the lip fits as the non-SCC oral cancer described.