Which intraoral effect is caused by antihypertensives, antidepressants, antihistamines, and diuretics?

• A. Xerostomia
• B. Oral candidiasis
• C. Gingival hyperplasia
• D. Dental attrition

Answer: (A)

The key idea is that these drug classes commonly reduce saliva production, either because they have anticholinergic effects or because they cause dehydration. Saliva keeps the mouth moist, buffers acids, and helps clear debris. When salivary flow drops, the mouth feels dry—xerostomia. This is the direct intraoral change caused by antihypertensives, antidepressants, antihistamines, and diuretics. Dry mouth can then lead to complications like increased caries risk or mucosal irritation and can contribute to infections such as candidiasis, but the characteristic intraoral effect tied to this medication group is xerostomia. Gingival hyperplasia, dental attrition, and primary oral candidiasis are not the typical direct effects of this combination.