Adverse intraoral effect from intravenous bisphosphonates is?

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Multiple Choice

Adverse intraoral effect from intravenous bisphosphonates is?

Explanation:
Intravenous bisphosphonates can cause osteonecrosis of the jaw because they profoundly inhibit osteoclast-mediated bone remodeling at high, cancer-dose levels. The jawbone undergoes constant remodeling due to chewing and dental microtrauma; when remodeling is suppressed, areas of microdamage don’t heal well, leading to exposed, necrotic bone that can get infected. This risk is especially high with IV formulations and invasive dental procedures, which is why BRONJ is the classic intraoral adverse effect in patients receiving IV bisphosphonates. Gingival overgrowth, caries, and stomatitis are not the characteristic jaw-complication pattern associated with IV bisphosphonates.

Intravenous bisphosphonates can cause osteonecrosis of the jaw because they profoundly inhibit osteoclast-mediated bone remodeling at high, cancer-dose levels. The jawbone undergoes constant remodeling due to chewing and dental microtrauma; when remodeling is suppressed, areas of microdamage don’t heal well, leading to exposed, necrotic bone that can get infected. This risk is especially high with IV formulations and invasive dental procedures, which is why BRONJ is the classic intraoral adverse effect in patients receiving IV bisphosphonates. Gingival overgrowth, caries, and stomatitis are not the characteristic jaw-complication pattern associated with IV bisphosphonates.

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